反应详情

6-chloro-3-[(2-fluoro-4-iodophenyl)amino]pyridazine-4-carboxylic acid (32 mg, 0.08 mmol.) and 1,1′-carbonylbis(1H-imidazole) (15.4 mg, 0.09 mmol) were suspended in N,N-dimethylformamide (0.6 ml). The mixture was stirred over night (12 hr). Morpholine (21.2 mg, 0.16 mmol) was then added. The reaction was stirred for another 5 h. Water (0.5 mL) was then added into the mixture. The desired product was precipitated and was collected by vacuum filtration. LC/MS [4.69 min; 506 (M+1)].

1. stirringThe reaction was stirred for another 5 h
2. customThe desired product was precipitated
3. filtrationwas collected by vacuum filtration
4. customLC/MS [4.69 min; 506 (M+1)]