Methyl 5-nitropicolinate → HCID 67151276, compound

HRID 2404259Notes

Reaction equation

HRID 2404259 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]([O:12]C)=O)=[N:8][CH:9]=1)([O-:3])=[O:2]>N1CCCCC1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]([N:8]2[CH2:9][CH2:4][CH2:5][CH2:6][CH2:7]2)=[O:12])=[N:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 1

HCID 12457882Methyl 5-nitropicolinate

Product 1

HCID 67151276HCID 67151276, compound

Reagents, catalysts & solvents 1

HCID 8082PiperidineSolvent

Procedure

Methyl 5-nitropyridine-2-carboxylate (182 g, 1 mol) was refluxed in piperidine (250 mL) for 1 hour. The reaction mixture was concentrated in vacuo to give crude 5-nitro-2-(piperidin-1-ylcarbonyl)pyridine, which was used for the next stage without additional purification.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-7189845501844ad99b93ddd3866f2d67
Source dataset
uspto-grants-2014_08
Patent number
US08802690B2

Reaction notes

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