4-(Bromomethyl)benzonitrile → HCID 66677749, compound

HRID 2404341Notes

Reaction equation

HRID 2404341 reaction equation
[C:1]([C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Br)=[CH:5][CH:4]=1)#[N:2].Cl.[CH3:12][NH:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18]>>[C:1]([C:3]1[CH:10]=[CH:9][C:6]([CH2:7][N:13]([CH3:12])[CH2:14][CH2:15][CH2:16][C:17]([O:19][C:20]([CH3:22])([CH3:21])[CH3:23])=[O:18])=[CH:5][CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 869964-(Bromomethyl)benzonitrileHCID 50988532tert-butyl 4-(methylamino)butanoate hydrochloride

Product 1

HCID 66677749HCID 66677749, compound

Procedure

The title compound was prepared following general procedure 10, starting from 4-cyanobenzyl bromide and tert-butyl 4-(methylamino)butanoate hydrochloride (Watanabe). It was obtained as a yellow oil (586 mg, quantitative). LC/MS (Method B): 289.2 (M+H)+. HPLC (Method A) Rt 3.02 (Purity: 91.8%).

Workup

  1. customIt was obtained as a yellow oil (586 mg, quantitative)

Sources & evidence

ORD record
ord-6b65213db08f465892d487607097486e
Source dataset
uspto-grants-2014_08
Patent number
US08802704B2

Reaction notes

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