Methyl iodide → HCID 68486741, compound

HRID 2404529Notes

Reaction equation

HRID 2404529 reaction equation
[F:1][C:2]1[CH:8]=[C:7]([CH3:9])[C:6]([SH:10])=[CH:5][C:3]=1[NH2:4].[C:11](=O)([O-])[O-].[K+].[K+].IC>O>[F:1][C:2]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10][CH3:11])=[CH:5][C:3]=1[NH2:4]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 42629164HCID 42629164, compound

Product 1

HCID 68486741HCID 68486741, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9.2 g of 2-fluoro-4-methyl-5-mercaptoaniline disclosed in WO2006/043635 was dissolved in 70 mL of water, and 9.7 g of potassium carbonate and 8.3 g of iodomethane were added under cooling with ice, followed by stirring at room temperature for 2 hours. The formed crystals were collected by filtration and washed with water to obtain 10.0 g of 2-fluoro-4-methyl-5-methylthioaniline.

Workup

  1. temperatureunder cooling with ice
  2. filtrationThe formed crystals were collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-a07b3167e0fc4e0aa5901c82c7456103
Source dataset
uspto-grants-2014_08
Patent number
US08802713B2

Reaction notes

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