Dimethylformamide dimethyl acetal → HCID 76548813, compound

HRID 2404665Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:18])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[C:7]([N+:14]([O-:16])=[O:15])[C:6]=1[CH3:17])[CH3:2].CO[CH:21]([N:24]([CH3:26])[CH3:25])OC>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:18])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[C:7]([N+:14]([O-:16])=[O:15])[C:6]=1[CH:17]=[CH:21][N:24]([CH3:26])[CH3:25])[CH3:2]

Participants

Conditions

Temperature: 100 °C

Procedure

A mixture of 2-methyl-3,5-dinitro-benzoic acid ethyl ester (35 g, 0.14 mol) and dimethoxymethyl-dimethyl-amine (32 g, 0.27 mol) in DMF (200 mL) was heated at 100° C. for 5 h. The mixture was poured into ice-water. The precipitate was collected via filtration and washed with water to give 2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester (11.3 g, 48%).

Workup

filtrationThe precipitate was collected via filtration
washwashed with water

Sources & evidence

ORD record: ord-71850d019a62483faf796060cca229fc
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08802700B2

Reaction notes

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