Ammonia → Ethyl 2-amino-1-benzothiophene-3-carboxylate

HRID 2404947Notes

Reaction equation

HRID 2404947 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]2[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=2[S:9][C:10]=1[NH:11]C(C1CC1)=O)=[O:5])[CH3:2].N>CS(O)(=O)=O>[CH2:1]([O:3][C:4]([C:6]1[C:7]2[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=2[S:9][C:10]=1[NH2:11])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 5201131HCID 5201131, compound

Product 1

HCID 699464Ethyl 2-amino-1-benzothiophene-3-carboxylate

Reagents, catalysts & solvents 1

HCID 6395Methanesulfonic AcidSolvent

Procedure

The solution of 10 millimol VII in 50 milliliter methanesulfonic acid was stirred at room temperature for 48 hours. The reaction mixture was poured onto icecold 25% aqueous NH3 solution, the soliw was filtered off, washed with water and n-hexane, then dried.

Workup

  1. filtrationthe soliw was filtered off
  2. washwashed with water and n-hexane
  3. customdried

Sources & evidence

ORD record
ord-5ec9d8affff240c1bfbbef12f8c50f13
Source dataset
uspto-grants-2014_08
Patent number
US08802849B2

Reaction notes

Loading…