反应详情

温度

33 °C

A suspension of the product from Example 33B (52.5 mg, 0.16 mmol), 2-trifluoromethylbenzylamine (33.3 mg, 0.19 mmol), 1-hydroxybenzotriazole (30.1 mg, 0.20 mmol), 4-dimethylaminopyridine (4 mg, 0.03 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (34.3 mg, 0.24 mmol) in pyridine (7.0 mL) were stirred at 33° C. for 18 h. The reaction mixture was filtered through a glass microfiber frit and rinsed with methanol. The filtrate was concentrated and the residue was purified by silica gel chromatography (EtOAc, Rf=0.2) to afford the title compound. MS (APCI) m/z 491 (M+H)+.

1. filtrationThe reaction mixture was filtered through a glass microfiber frit
2. washrinsed with methanol
3. concentrationThe filtrate was concentrated
4. customthe residue was purified by silica gel chromatography (EtOAc, Rf=0.2)