反应详情

温度

50 °C

2-Methylbenzo[d]oxazol-5-ol (0.86 g, 5.77 mmol), 1-fluoro-2-methyl-4-nitrobenzene (0.98 g, 6.34 mmol) and K2CO3 (1.59 g, 11.53 mmol) were combined in DMF and heated to 50° C. for 16 hours. The reaction mixture was cooled to room temperature and poured into ice water. The mixture was extracted with ethyl acetate (3×). The combined organics were washed with brine, dried, and concentrated under reduced pressure. The residue was chromatographed (20% to 40% ethyl acetate in hexanes) to provide the product (0.671 g, 41%) as yellow solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionThe mixture was extracted with ethyl acetate (3×)
3. washThe combined organics were washed with brine
4. customdried
5. concentrationconcentrated under reduced pressure
6. customThe residue was chromatographed (20% to 40% ethyl acetate in hexanes)