反应详情

6-methoxybenzo[d]thiazole hydrobromide (1.00 g, 4.06 mmol) was dissolved in aqueous hydrobromide (10 mL of 48% solution). After heating to reflux for 10 hours, the mixture was cooled in an ice bath and diluted with water (50 mL). After adjusting the pH to 8 with the slow addition of solid NaHCO3, the mixture was filtered, washing the solid with water and air-drying to provide the product (0.35 g, 57%) as white solid.

1. temperatureAfter heating
2. temperatureto reflux for 10 hours
3. temperaturethe mixture was cooled in an ice bath
4. filtrationthe mixture was filtered
5. washwashing the solid with water
6. customair-drying