Dimethylformamide dimethyl acetal → HCID 178428760, compound

HRID 240554Notes

Reaction equation

HRID 240554 reaction equation
[CH3:1][C:2]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([NH2:11])[CH:6]=1.CO[CH:21](OC)[N:22]([CH3:24])[CH3:23]>C(O)C>[CH3:21][N:22]([CH3:24])/[CH:23]=[N:11]\[C:7]1[CH:6]=[C:5]([O:4][C:3]2[CH:12]=[CH:13][C:14]([N+:16]([O-:18])=[O:17])=[CH:15][C:2]=2[CH3:1])[CH:10]=[CH:9][N:8]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 231530654-(2-Methyl-4-nitrophenoxy)pyridin-2-amine

Product 1

HCID 178428760HCID 178428760, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 4-(2-methyl-4-nitrophenoxy)pyridin-2-amine (2.05 g, 8.34 mmol) in ethanol (9 mL) was added dimethoxy-N,N-dimethylmethanamine (1.18 mL, 8.34 mmol). After heating to 80° C. for 1 hour, the mixture was concentrated under reduced pressure to provide the crude product as dark oil.

Workup

  1. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-10476781d2334df78bb477caee31f24e
Source dataset
uspto-grants-2014_02
Patent number
US08648087B2

Reaction notes

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