反应详情

To a solution of concentrated aqueous HCl (10 mL) in methanol (10 mL) was added N-(3-methyl-4-(1-methyl-1H-benzo[d]imidazol-5-yloxy)phenyl)formamide (1.70 g, 6.04 mmol). After heating to reflux for 2 hours, the reaction mixture was cooled to room temperature and diluted with water (100 mL). The mixture was neutralized with sodium bicarbonate and extracted with dichloromethane. The organic solution was dried over Na2SO4, filtered and concentrated under reduced pressure to provide the product.

1. temperatureAfter heating
2. temperatureto reflux for 2 hours
3. extractionextracted with dichloromethane
4. dry with materialThe organic solution was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure
7. customto provide the product