Dimethylformamide dimethyl acetal → HCID 178484249, compound

HRID 240581Notes

Reaction equation

HRID 240581 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH2:15])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO[CH:18](OC)[N:19]([CH3:21])[CH3:20]>C(O)(C(F)(F)F)=O.C(O)C>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11](/[N:15]=[CH:18]\[N:19]([CH3:21])[CH3:20])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 5200844-(Benzyloxy)pyridin-2-amine

Product 1

HCID 178484249HCID 178484249, compound

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidCatalystHCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

A 250 mL, single-neck, round-bottomed flask was charged with 4-(benzyloxy)pyridin-2-amine (6.012 g, 30.02 mmol), dimethoxy-N,N-dimethylmethanamine (5.535 ml, 39.03 mmol) and ethanol (100.1 ml). A few drops of TFA were added and the reaction was heated to 50° C. for 4 hours. The reaction was cooled to ambient temperature and concentrated. The crude product was used in the next step without purification.

Workup

  1. temperatureThe reaction was cooled to ambient temperature
  2. concentrationconcentrated
  3. customThe crude product was used in the next step without purification

Sources & evidence

ORD record
ord-10afaab77816499b940319a831dcd343
Source dataset
uspto-grants-2014_02
Patent number
US08648087B2

Reaction notes

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