反应详情

温度

0 °C

Trifluoroacetic anhydride (2.62 mL, 18.9 mmol) was added dropwise to a solution of (Z)-N′-(4-(benzyloxy)pyridin-2-yl)-N-hydroxyformamidine (4.37 g, 17.9 mmol) in THF (180 mL), and the mixture was cooled to 0° C. The ice bath was then removed and the reaction was stirred for 12 hours. The reaction was concentrated to about 15-25 mL, then poured into 400 mL of iced 1 M NaOH. The mixture was stirred for 1 hour. The resulting white solids were collected by filtration, washed with hexanes, and dried under high vacuum for 1 hour to provide the desired product.

1. customThe ice bath was then removed
2. concentrationThe reaction was concentrated to about 15-25 mL
3. additionpoured into 400 mL of iced 1 M NaOH
4. stirringThe mixture was stirred for 1 hour
5. filtrationThe resulting white solids were collected by filtration
6. washwashed with hexanes
7. customdried under high vacuum for 1 hour