7-(Benzyloxy)-[1,2,4]triazolo[1,5-a]pyridine → HCID 178516352, compound

HRID 240584Notes

Reaction equation

HRID 240584 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][N:12]2[N:15]=[CH:16][N:17]=[C:11]2[CH:10]=1)C1C=CC=CC=1>[Pd].C1COCC1>[N:17]1[CH:16]=[N:15][N:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]=12

Participants

4

Reactant 1

HCID 669371067-(Benzyloxy)-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 178516352HCID 178516352, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A 250 mL, single-neck, round-bottomed flask was charged with 7-(benzyloxy)-[1,2,4]triazolo[1,5-a]pyridine (3.20 g, 14.2 mmol), Pd/C (0.756 g, 0.710 mmol), and THF (125 mL). The reaction was stirred under an atmosphere of hydrogen for 16 hours, then filtered (GF paper) and concentrated to a white solid. The solids were titrated with EtOAc and collected by filtration to provide the desired product.

Workup

  1. filtrationfiltered (GF paper)
  2. concentrationconcentrated to a white solid
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-8dc86bf5530f48a88256ee9f41785e31
Source dataset
uspto-grants-2014_02
Patent number
US08648087B2

Reaction notes

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