反应详情

(S)-1-(3-(5-chloro-2-nitrophenoxy)piperidin-1-yl)-2,2,2-trifluoroethanone (465.0 mg) and SnCl2*H2O (1.49 g) was dissolved in EtOAc (10.0 ml) and heated at reflux for 3.5 h. The reaction mixture was diluted with EtOAc an 10% aq. K2CO3. The mixture was separated and the organic layer washed with water and brine. The organic phase was dried and poured through an hydrophobic frit. The solvent was evaporated to give the intended product.

1. temperatureheated
2. temperatureat reflux for 3.5 h
3. customThe mixture was separated
4. washthe organic layer washed with water and brine
5. customThe organic phase was dried
6. additionpoured through an hydrophobic frit
7. customThe solvent was evaporated
8. customto give the intended product