Water → HCID 57704525, compound

HRID 2406036Notes

Reaction equation

HRID 2406036 reaction equation
[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]([CH2:31][O:32][CH2:33][O:34][CH3:35])([CH2:22][CH2:23][O:24][CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][O:26]1)[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:43](Br)[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49].O>CN(C)C=O>[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]([CH2:31][O:32][CH2:33][O:34][CH3:35])([CH2:22][CH2:23][O:24][CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][O:26]1)[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49])=[C:13]([C:18]([F:20])([F:21])[F:19])[CH:12]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 123691-BromoheptaneHCID 57704569HCID 57704569, compound

Product 1

HCID 57704525HCID 57704525, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

Compound 21-6 (1.24 g) was dissolved in N,N-dimethylformamide (20 ml), potassium carbonate (986 mg) and n-heptyl bromide (0.458 ml) were added, and the mixture was stirred at 80° C. for 2.5 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate, washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the object product (1.49 g) as a pale-yellow oil.

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washwashed with water and saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-7de81bec56824c20a8f4e519609addcd
Source dataset
uspto-grants-2014_08
Patent number
US08809304B2

Reaction notes

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