Hydrochloric Acid → HCID 67419769, compound
Reaction equation
C(OC(=O)[NH:7][C:8]([CH2:38][O:39]COC)([CH2:29][CH2:30][O:31]C1CCCCO1)[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[C:13]([C:25]([F:28])([F:27])[F:26])[CH:12]=1)(C)(C)C.[ClH:44]>C(O)C>[ClH:44].[NH2:7][C:8]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[C:13]([C:25]([F:26])([F:27])[F:28])[CH:12]=1)([CH2:29][CH2:30][OH:31])[CH2:38][OH:39]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
Compound 21-7 (1.49 g) was dissolved in ethanol (20 ml), concentrated hydrochloric acid (3 ml) was added, and the mixture was stirred at 80° C. for 1.5 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (915 mg) as a white powder.
Workup
- concentrationThe reaction mixture was concentrated
- washthe residue was washed with diethyl ether
Sources & evidence
- ORD record
- ord-28620edbc043495cac1bc80e9300ebac
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08809304B2
Reaction notes
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