Hydrochloric Acid → HCID 58413034, compound

HRID 240604Notes

Reaction equation

HRID 240604 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:34][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][CH:22]3[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23]3)[C:7]=2[C:6]=1[CH3:35])=[O:4].Cl>CO.O1CCOCC1>[CH3:1][O:2][C:3]([C:5]1[S:34][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][CH:22]3[CH2:26][CH2:25][NH:24][CH2:23]3)[C:7]=2[C:6]=1[CH3:35])=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58413170HCID 58413170, compound

Product 1

HCID 58413034HCID 58413034, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a stirred suspension of 4-[2-(1-tert-Butoxycarbonyl-pyrrolidin-3-yloxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (1.2 g) in MeOH (4.0 ml) was added HCl in dioxane (4N; 4.0 ml) dropwise. The reaction mixture was stirred for 8 h. The solvent was removed under reduced pressure. The residue was purified by chromatography.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customThe residue was purified by chromatography

Sources & evidence

ORD record
ord-986b089dd36e411a83875bff96fc24eb
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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