反应详情

温度

110 °C

To a stirred solution of benzyltributyltin (69 mg, 0.184 mmol) and 8a (19.5 mg, 0.0525 mmol) in a mixture of 2 mL of DMF and 1 mL of NEt3, was added Pd(PPh3)4 (6.0 mg, 5.3 μmol). The seal tube was sealed under argon and the mixture was stirred at 110° C. for 18 h. The reaction the mixture was cooled and concentrated to dryness in vacuo and the crude product was purified by chromatography on a silica gel column. Elution with n-heptane/EtOAc (2:1) as eluent yielded 16a as a white solid (13 mg, 65%). mp: 299° C.,

1. customThe seal tube was sealed under argon
2. customThe reaction the mixture
3. temperaturewas cooled
4. concentrationconcentrated to dryness in vacuo
5. customthe crude product was purified by chromatography on a silica gel column
6. washElution with n-heptane/EtOAc (2:1) as eluent