Hydrochloric Acid → HCID 58413035, compound

HRID 240626Notes

Reaction equation

HRID 240626 reaction equation
Cl.[C:2]([C:5]1[S:34][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[C:15]([O:20][C@H:21]4[CH2:26][CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22]4)=[N:16][CH:17]=[CH:18][CH:19]=3)[C:7]=2[C:6]=1[CH3:35])(=[O:4])[NH2:3]>O1CCOCC1.CO>[CH3:35][C:6]1[C:7]2[C:12]([NH:13][C:14]3[C:15]([O:20][C@H:21]4[CH2:26][CH2:25][CH2:24][NH:23][CH2:22]4)=[N:16][CH:17]=[CH:18][CH:19]=3)=[N:11][CH:10]=[N:9][C:8]=2[S:34][C:5]=1[C:2]([NH2:3])=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58413189HCID 58413189, compound

Product 1

HCID 58413035HCID 58413035, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

HCl in Dioxane (4M; 4 ml) was added into a solution of (S)-tert-butyl 3-(3-(6-carbamoyl-5-methylthieno[2,3-d]pyrimidin-4-ylamino)pyridin-2-yloxy)piperidine-1-carboxylate (250 mg) in Methanol (8 ml). The reaction was stirred at room temperature for 1.5 h. The solution was purified by chromatography.

Workup

  1. customThe solution was purified by chromatography

Sources & evidence

ORD record
ord-f1b5d33a9e8244799d615e91d17c65b4
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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