HRID2406357

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CS(=O)(=O)N1CC=C(c2cc3c(cn2)OC2(C3)CC3(CCN(C#N)CC3)C2)CC1

HCID86701203

未命名化合物

HCID178449908

未命名化合物

PRODUCTS

生成物

结构：CC(C)c1noc(N2CCC3(CC2)CC2(Cc4cc(C5=CCN(S(C)(=O)=O)CC5)ncc4O2)C3)n1

HCID72194980

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID3007855

Zinc chloride

Cl2Zn

溶剂HCID8028

Tetrahydrofuran

C4H8O

溶剂HCID8857

Ethyl acetate

C4H8O2

CONDITIONS

反应条件

温度: 60 °C

PROCEDURE

实验过程

Zinc chloride (0.7 mol/L in tetrahydrofuran, 0.42 mL) is added to a solution of N-hydroxy-isobutyramidine (30 mg) and 1″-cyano-5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1′-cyclobutane-3′,4″-piperidine] (100 mg) in tetrahydrofuran (4 mL) and ethyl acetate (4 mL) at room temperature. The solution is heated to 60° C. and stirred at this temperature for 2 h.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c2fb4b0c5e3f4020b99e13518561b7b9
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08809361B2
来源说明: uspto-grants-2014_08

反应 SMILES

[OH:1][NH:2][C:3](=[NH:7])[CH:4]([CH3:6])[CH3:5].[C:8]([N:10]1[CH2:15][CH2:14][C:13]2([CH2:18][C:17]3([O:36][C:21]4=[CH:22][N:23]=[C:24]([C:26]5[CH2:27][CH2:28][N:29]([S:32]([CH3:35])(=[O:34])=[O:33])[CH2:30][CH:31]=5)[CH:25]=[C:20]4[CH2:19]3)[CH2:16]2)[CH2:12][CH2:11]1)#N>O1CCCC1.C(OCC)(=O)C.[Cl-].[Zn+2].[Cl-]>[CH:4]([C:3]1[N:7]=[C:8]([N:10]2[CH2:11][CH2:12][C:13]3([CH2:18][C:17]4([O:36][C:21]5=[CH:22][N:23]=[C:24]([C:26]6[CH2:31][CH2:30][N:29]([S:32]([CH3:35])(=[O:33])=[O:34])[CH2:28][CH:27]=6)[CH:25]=[C:20]5[CH2:19]4)[CH2:16]3)[CH2:14][CH2:15]2)[O:1][N:2]=1)([CH3:6])[CH3:5]