HRID2406654

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID516892

Sodium Bicarbonate

CHNaO3

HCID643189

D-alpha-Methylbenzylamine

C8H11N

反应SMILES：CCCCCCc1c(C(=O)C[C@@H](C)CC(=O)O)c2cc(Cl)ccc2n1C

HCID49802026

未命名化合物

PRODUCTS

产物

反应SMILES：CCCCCCc1c(C(=O)C[C@@H](C)CC(=O)NC(C)c2ccccc2)c2cc(Cl)ccc2n1C

HCID49802587

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

PROCEDURE

实验过程

To the solution of 5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoic acid in methylene chloride was added (R)-1-phenylethanamine followed by the addition of DCC and DMAP and was stirred for 30 minutes. The reaction mixture was treated with sodium bicarbonate and methylene chloride. The product was purified by column chromatography.

WORKUP

后处理

customThe product was purified by column chromatography

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-e1d62f99f2d5418c916fd3ff7f643afc
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08809382B2
来源说明: uspto-grants-2014_08

反应SMILES

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[C:5]2[C:18](=[O:26])[CH2:19][C@@H:20]([CH3:25])[CH2:21][C:22](O)=[O:23].[C:27]1([C@H:33]([NH2:35])[CH3:34])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.C1CCC(N=C=NC2CCCCC2)CC1.C(=O)(O)[O-].[Na+]>C(Cl)Cl.CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[C:5]2[C:18](=[O:26])[CH2:19][C@@H:20]([CH3:25])[CH2:21][C:22]([NH:35][CH:33]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH3:34])=[O:23]