反应详情

Triethylamine (191 mg) and morpholine (120 mg) were added to a tetrahydrofuran (4 ml) solution containing 3-bromo-2-chloro-5-nitropyridine (300 mg), followed by stirring for 40 minutes. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate. Subsequently, the solvent was distilled away under reduced pressure, the obtained residue was purified by silica gel chromatography (chloroform:methanol=1:0 to 3:1), and a yellow solid of 4-(3-bromo-5-nitropyridin-2-yl)morpholine (346 mg) was thus obtained.

1. extractionfollowed by extraction with ethyl acetate
2. washThe resultant was washed with saturated saline
3. dry with materialdried over anhydrous sodium sulfate
4. distillationSubsequently, the solvent was distilled away under reduced pressure
5. customthe obtained residue was purified by silica gel chromatography (chloroform:methanol=1:0 to 3:1)