Potassium Carbonate → 6-(4,4-Difluoropiperidin-1-yl)-5-phenyl-1,2,4-triazin-3-amine

HRID 2407144Notes

Reaction equation

HRID 2407144 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C([O-])([O-])=O.[K+].[K+].Cl.[F:22][C:23]1([F:29])[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[F:22][C:23]1([F:29])[CH2:28][CH2:27][N:26]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 27583514,4-Difluoropiperidine hydrochlorideHCID 866761156-Chloro-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 673637236-(4,4-Difluoropiperidin-1-yl)-5-phenyl-1,2,4-triazin-3-amineYield 14%

Procedure

6-(4,4-Difluoropiperidin-1-yl)-5-phenyl-1,2,4-triazin-3-amine (39 mg, 14%) was prepared from 6-chloro-5-phenyl-1,2,4-triazin-3-amine (0.20 g, 0.96 mmol), K2CO3 (0.23 g, 1.67 mmol) and 4,4-difluoropiperidine hydrochloride (0.22 g, 1.45 mmol) according to the general procedure of Example 2.

Sources & evidence

ORD record
ord-adc3551a70454aefbab6123c9cb9e87f
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

Loading…