Potassium Carbonate → 2-(N-Pyrimidin-2-ylhydrazino)ethanol

HRID 2407387Notes

Reaction equation

HRID 2407387 reaction equation
Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:8]([CH:10](O)[CH3:11])[NH2:9].C(=O)([O-])[O-:14].[K+].[K+]>C(O)C>[N:3]1[CH:4]=[CH:5][CH:6]=[N:7][C:2]=1[N:8]([CH2:10][CH2:11][OH:14])[NH2:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 744042-ChloropyrimidineHCID 19013750Hydrazinoethanol

Product 1

HCID 584160282-(N-Pyrimidin-2-ylhydrazino)ethanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.8 g (41.9 mmol) of 2-chloropyrimidine in 100 ml of ethanol and 3.6 g (47 mmol) of hydrazinoethanol and 9 g (64.2 mmol) of potassium carbonate were heated under reflux for 5 h. The mixture was filtered off with suction and the filtrate was concentrated by evaporation.

Workup

  1. temperatureunder reflux for 5 h
  2. filtrationThe mixture was filtered off with suction
  3. concentrationthe filtrate was concentrated by evaporation

Sources & evidence

ORD record
ord-7780fa72642443dd9b1df9a28bc8889e
Source dataset
uspto-grants-2014_08
Patent number
US08809547B2

Reaction notes

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