Hydrogen Peroxide → ADONA

HRID 2407651Notes

Reaction equation

HRID 2407651 reaction equation
OO.FC(F)(F)C(C(F)(F)F)=[O:6].[F:13][C:14]([F:34])([CH:17]([F:33])[O:18][C:19]([F:32])([F:31])[C:20]([F:30])([F:29])[C:21]([F:28])([F:27])[O:22][C:23]([F:26])([F:25])[F:24])[CH2:15][OH:16]>C(Cl)(Cl)Cl>[F:13][C:14]([F:34])([CH:17]([F:33])[O:18][C:19]([F:32])([F:31])[C:20]([F:29])([F:30])[C:21]([F:27])([F:28])[O:22][C:23]([F:24])([F:25])[F:26])[C:15]([OH:6])=[O:16]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 12695HexafluoroacetoneHCID 866682301-Propanol, 2,2,3-trifluoro-3-[1,1,2,2,3,3-hexafluoro-3-(trifluoromethoxy)propoxy]-

Product 1

HCID 52915299ADONA

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 2.3 mL (22 mmol) of 30% H2O2 in 20 mL of chloroform, 13.28 g (80 mmol) of hexafluoroacetone (pre-generated from HFA-hydrate) was added followed by 2,2,3-trifluoro-3-(1,1,2,2,3,3-hexafluoro-3-trifluoromethoxy-propoxy)-propan-1-ol (3.64 g, 10 mmol). The mixture was stirred 2 days at room temperature. After separation of phases and evaporation of solvent, the residue was examined by 19F NMR spectroscopy. Yield of the raw product 52%.

Workup

  1. customAfter separation of phases and evaporation of solvent

Sources & evidence

ORD record
ord-40db77a94d6947eb92d4f953230966d9
Source dataset
uspto-grants-2014_08
Patent number
US08809580B2

Reaction notes

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