[5-(2-PYRIDINYL)-2-THIENYL]METHANOL → 5-(Pyridin-2-yl)thiophene-2-carbaldehyde

HRID 2407664Notes

Reaction equation

HRID 2407664 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([CH2:12][OH:13])=[CH:9][CH:8]=1>O1CCCC1.[O-2].[O-2].[Mn+4]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([CH:12]=[O:13])=[CH:9][CH:8]=1

Participants

4

Reactant 1

HCID 2776202[5-(2-PYRIDINYL)-2-THIENYL]METHANOL

Product 1

HCID 6051275-(Pyridin-2-yl)thiophene-2-carbaldehydeYield 8,307.6%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A solution of (5-(pyridin-2-yl)thien-2-yl) methanol (0.100 g) and manganese dioxide (0.136 g) in tetrahydrofuran (3.5 mL) was refluxed overnight. The mixture was cooled to room temperature and the solids were filtered. The filtrate was concentrated and the residue was triturated (hexane:diethyl ether=1:1) to obtain the title compound (8.22 g) having the following physical data.

Workup

  1. filtrationthe solids were filtered
  2. concentrationThe filtrate was concentrated
  3. customthe residue was triturated (hexane:diethyl ether=1:1)

Sources & evidence

ORD record
ord-27bbdf48b6e240269cf7de43153fb030
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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