反应详情

A solution of the compound prepared in Example 57 (600 mg) in trifluoroacetic acid (2 mL)-aqueous 18% hydrochloric acid (4 mL) was refluxed for two hours. The reaction was cooled to room temperature and concentrated to obtain the title compound (699 mg) having the following physical data. 1H NMR (DMSO-d6): δ 11.26-11.11 (m, 1H), 7.94-7.85 (m, 2H), 7.61-7.50 (m, 3H), 7.37 (s, 1H), 4.56 (s, 2H), 3.51-3.39 (m, 2H), 3.12-2.97 (m, 2H), 2.23-2.15 (m, 2H), 1.99-1.82 (m, 3H), 1.65-1.49 (m, 2H).

1. concentrationconcentrated