Hydrochloric Acid → HCID 66989815, compound

HRID 2407685Notes

Reaction equation

HRID 2407685 reaction equation
[Cl:1][C:2]1[C:11]([Cl:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]([CH2:14][CH:15]1[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]1)[C:7]2=[O:13].Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[C:11]([Cl:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]([CH2:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:7]2=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58504162HCID 58504162, compound

Product 1

HCID 66989815HCID 66989815, compoundYield 189.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound prepared in Example 76 (0.05 g) was suspended in 1,4-dioxane (4 mL), hydrochloric acid (4 mol/L solution in 1,4-dioxane, 0.88 mL) was added and the reaction mixture was stirred at room temperature overnight. The reaction mixture was concentrated to obtain the title compound (0.04 g) having the following physical data.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-14fc4418fa0a4d1b93f542c4c3a3f2db
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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