Hydrochloric Acid → HCID 178498874, compound

HRID 2407712Notes

Reaction equation

HRID 2407712 reaction equation
O.[C:2]1([C:8]2[NH:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[OH-].[Na+].[CH3:19]O>C(OC(=O)C)C>[C:2]1([C:8]2[NH:9][CH:10]=[C:11]([C:13]([O:15][CH3:19])=[O:14])[N:12]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 178526952HCID 178526952, compound

Product 1

HCID 178498874HCID 178498874, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-Phenyl-1H-imidazole-4-carboxylic acid mono hydrate (2.00 g) was suspended in methanol (30 mL) and concentrated hydrochloric acid (10.0 mL) was added and the reaction mixture heated at reflux overnight. The reaction mixture was cooled to room temperature and diluted with ethylacetate and the aqueous basified with 1 N sodium hydroxide. The organics were washed with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the title compound. The title compound was used without further purification, having the following physical data.

Workup

  1. temperaturethe reaction mixture heated
  2. temperatureat reflux overnight
  3. washThe organics were washed with brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-fc0c82ef86e44d54a0ffa9cda6a72d99
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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