Trifluoroacetic acid → HCID 86659057, compound

HRID 2407724Notes

Reaction equation

HRID 2407724 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([CH2:23][C:24]3[S:28][C:27]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=4)=[N:26][C:25]=3[CH2:35][N:36]3[CH2:41][CH2:40][N:39](C(OC(C)(C)C)=O)[CH2:38][CH2:37]3)[CH2:19][CH2:18]2)=[O:14])[CH:3]=1.[F:49][C:50]([F:55])([F:54])[C:51]([OH:53])=[O:52]>ClCCl>[F:49][C:50]([F:55])([F:54])[C:51]([OH:53])=[O:52].[F:49][C:50]([F:55])([F:54])[C:51]([OH:53])=[O:52].[F:49][C:50]([F:55])([F:54])[C:51]([OH:53])=[O:52].[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][CH:17]2[CH2:18][CH2:19][N:20]([CH2:23][C:24]3[S:28][C:27]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=4)=[N:26][C:25]=3[CH2:35][N:36]3[CH2:37][CH2:38][NH:39][CH2:40][CH2:41]3)[CH2:21][CH2:22]2)=[O:14])[CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58503919HCID 58503919, compound

Product 1

HCID 86659057HCID 86659057, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the compound prepared in Example 159 (100 mg) in dichloromethane (1 mL)-trifluoroacetic acid (228 mL) was stirred for 30 minutes. The reaction was concentrated and the excess trifluoroacetic acid was removed via azeotropic distillation from toluene and hexane to obtain the title compound (110 mg) having the following physical data.

Workup

  1. concentrationThe reaction was concentrated
  2. customthe excess trifluoroacetic acid was removed via azeotropic distillation from toluene and hexane

Sources & evidence

ORD record
ord-3c713ea185de478fa58bc9e33b617008
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

Loading…