反应详情

温度

80 °C

To a solution of the compound prepared in Example 279 (0.317 g) in N,N-dimethylformamide (6 mL) was added potassium cyanide (0.100 g) at room temperature. The mixture was heated at 80° C. for 18 hours and then cooled to room temperature. The solids were filtered, and the filtrate diluted with ethyl acetate, washed with 1N hydrochloric acid and water. The organic layer was filtered, evaporated in vacuo and purified by column chromatography on silica gel (10-50% ethyl acetate in hexane) to obtain the title compound (0.096 g) having the following physical data.

1. temperaturecooled to room temperature
2. filtrationThe solids were filtered
3. additionthe filtrate diluted with ethyl acetate
4. washwashed with 1N hydrochloric acid and water
5. filtrationThe organic layer was filtered
6. customevaporated in vacuo
7. custompurified by column chromatography on silica gel (10-50% ethyl acetate in hexane)