反应详情

To a suspension of the compound prepared in Example 280 (0.672 g) in hydrochloric acid (2.3 mL) and methanol (7 mL) was added portionwise iron (0.680 g) slowly. After addition was complete, the mixture was stirred at room temperature for 1 hour. The mixture was evaporated in vacuo, diluted with dichloromethane, filtered, and purified by column chromatography on silica gel (5-70% ethyl acetate in hexane) to obtain the title compound (0.460 g) having the following physical data.

1. additionAfter addition
2. customThe mixture was evaporated in vacuo
3. additiondiluted with dichloromethane
4. filtrationfiltered
5. custompurified by column chromatography on silica gel (5-70% ethyl acetate in hexane)