反应详情

A solution of methyl 3′-formylbiphenyl-4-carboxylate (0.338 g) was dissolved in 2 mol/L dimethylamine in tetrahydrofuran (20 mL) and stirred at room temperature for 1 hour. Sodium triacetoxyborohydride (0.895 g) was added. The reaction was stirred at room temperature for 5 days and then partitioned between saturated aqueous sodium bicarbonate and ethyl acetate. The organics were dried over magnesium sulfate and concentrated under reduced pressure to afford the crude material, which was purified by flash column chromatography (eluant: 0-5% methanol/dichloromethane (0.5% triethylamine) to furnish the title compound (0.112 g) having the following physical data.

1. stirringThe reaction was stirred at room temperature for 5 days
2. custompartitioned between saturated aqueous sodium bicarbonate and ethyl acetate
3. dry with materialThe organics were dried over magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customto afford the crude material, which
6. customwas purified by flash column chromatography (eluant