反应详情

A mixture of the compound prepared in Example 424 (1.8 g) in N,N-dimethylformamide (25 mL) was treated with potassium carbonate (1.76 g), followed by iodomethane (2.65 mL). The mixture was stirred at room temperature overnight. The solvent was concentrated in vacuo and the residue diluted with water, crude precipitated solids were collected by filtration, 2.14 g. These solids were taken in dichloromethane and purified by column chromatography on silica gel (5-25% ethyl acetate in hexanes) to provide the title compound (1.16 g) having the following physical data.

1. concentrationThe solvent was concentrated in vacuo
2. additionthe residue diluted with water, crude
3. customprecipitated solids
4. filtrationwere collected by filtration, 2.14 g
5. custompurified by column chromatography on silica gel (5-25% ethyl acetate in hexanes)