反应详情

温度

80 °C

To a stirred solution of the compound prepared in Example 426 (0.048 g) in N,N-dimethylformamide (1.2 mL) was added N-chlorosuccinimide (0.0343 g). The resulting mixture was heated at 80° C. for 18 hours. The solvent was evaporated and the residue dissolved in dichloromethane and purified by column chromatography on silica gel (20% ethyl acetate in hexanes) to obtain the title compound (0.003 g) having the following physical data.

1. customThe solvent was evaporated
2. dissolutionthe residue dissolved in dichloromethane
3. custompurified by column chromatography on silica gel (20% ethyl acetate in hexanes)