Ammonium formate → HCID 21876486, compound

HRID 240822Notes

Reaction equation

HRID 240822 reaction equation
[CH3:1][O:2][C:3](=[O:15])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][C:6]=1[CH3:14].C([O-])=O.[NH4+]>C1COCC1.CO.[Pd]>[CH3:1][O:2][C:3](=[O:15])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][C:6]=1[CH3:14]

Participants

6

Reactant 2

HCID 2723923Ammonium formateHCID 10081813HCID 10081813, compound

Product 1

HCID 21876486HCID 21876486, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-methyl-4-nitro phenylacetic acid methyl ester (10 mmol) in dry THF (20 mL) and methyl alcohol (20 mL), ammonium formate (0.1 mol) and 10% Pd/C (0.5 g) have been added and the resulting mixture has been left stirring for 3 h, until complete disappearance of the starting reagent. The catalyst has been filtered off and the filtrate evaporated under vacuum to give 2-methyl-4-amino phenylacetic acid methyl ester as a waxy solid (9.22 mmol).

Workup

  1. waitthe resulting mixture has been left
  2. filtrationThe catalyst has been filtered off
  3. customthe filtrate evaporated under vacuum

Sources & evidence

ORD record
ord-4b3459b6e04c421ab32543eb6773469d
Source dataset
uspto-grants-2014_02
Patent number
US08648110B2

Reaction notes

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