反应详情

Dry triethylamine (0.38 mL, 2.8 mmol) and methyl 3-(2-hydroxyphenyl)propanoate, 80 (0.5 g, 2.77 mmol) in dry ether (9.2 mL) were added dropwise to a solution of dry ether (5 mL) containing phosphorus oxychloride (0.25 mL, 2.8 mmol) at −78° C. under nitrogen. Following the addition, the reaction mixture was slowly allowed to warm at room temperature, and stirred for 1 h. The solvent was removed under reduced pressure to give crude product as an oil containing significant amount of solid.

1. additionthe addition
2. customThe solvent was removed under reduced pressure
3. customto give crude product as an oil
4. additioncontaining significant amount of solid