反应详情

Boc-β-Iodo-Ala-OMe (1.0 g, 3 mmol) was added to a slurry of zinc dust (0.596 g, 9 mmol) and I2 (0.2 mg) in 3 ml DMF under N2. The mixture was stirred for 1 h then Pd2 dba3 (0.070 g, 0.076 mmol), SPhos ligand (0.062 g, 0.15 mmol), and 1,3-cyclopentanedione (0.63 g, 3.9 mmol) were added. The reaction mixture was stirred over night. Purification by flash chromatography (0-100% EtOAc in iso-hexane) gave compound the title compound (0.468 g) in 70% yield. [M+H]+: 284.

1. stirringThe reaction mixture was stirred over night
2. customPurification by flash chromatography (0-100% EtOAc in iso-hexane)