反应详情

As shown in scheme Q, 2-amino-4,5-dimethoxybenzamide is reacted with 4-chlorobenzoyl chloride in presence of triethyl amine and THF to give 2-((4-chlorophenyl)carbonylamino)-4,5-dimethoxybenzamide. Which is cyclised using NaOH and then treated with thionyl chloride to give 4-chloro-2-(4-chlorophenyl)-6,7-dimethoxyquinazoline (McKee, R. L. et. al., J. Am. Chem. Soc., 1946, 68, 1902-1903). The 4-chlorocompound is treated with 5-(tert-butyl)selenophene-2-carboxamide in the presence of NaOH/DMF to give 3-(2-(4-chlorophenyl)-6,7-dimethoxyquinazolin-4-ylamino)-5-tert-butylselenophene-2-carboxamide.