Diisopropylethylamine → 3-(3-Hydroxypropylsulfanyl)-dihydrofuran-2-one

HRID 2409378Notes

Reaction equation

HRID 2409378 reaction equation
[SH:1][CH2:2][CH2:3][CH2:4][OH:5].CCN(C(C)C)C(C)C.Br[CH:16]1[CH2:20][CH2:19][O:18][C:17]1=[O:21]>CN(C=O)C>[OH:5][CH2:4][CH2:3][CH2:2][S:1][CH:16]1[CH2:20][CH2:19][O:18][C:17]1=[O:21]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 882113-MercaptopropanolHCID 954632(3H)-Furanone, 3-bromodihydro-

Product 1

HCID 661156623-(3-Hydroxypropylsulfanyl)-dihydrofuran-2-one

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 3-mercapto-propan-1-ol (1685 μmol) in DMF (2 ml) were added DIEA (1.5 eq) and 3-bromo-dihydro-furan-2-one (1 eq). The reaction mixture was stirred at RT for 4 hours. The precipitate was filtered and the solvent was removed under reduced pressure.

Workup

  1. filtrationThe precipitate was filtered
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-622915712cc9438191d83d881cb6d9a0
Source dataset
uspto-grants-2014_08
Patent number
US08815873B2

Reaction notes

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