Hydrochloric Acid → HCID 67410395, compound

HRID 2409417Notes

Reaction equation

HRID 2409417 reaction equation
[CH3:1][N:2]([CH3:24])[CH2:3][CH2:4][O:5][C:6]1[CH:23]=[CH:22][C:9]2[N:10](COC)[C:11](=[O:18])[C:12]3[CH2:13][CH2:14][CH2:15][NH:16][C:17]=3[C:8]=2[CH:7]=1.[ClH:25]>C(O)C>[ClH:25].[CH3:1][N:2]([CH3:24])[CH2:3][CH2:4][O:5][C:6]1[CH:23]=[CH:22][C:9]2[NH:10][C:11](=[O:18])[C:12]3[CH2:13][CH2:14][CH2:15][NH:16][C:17]=3[C:8]=2[CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58424926HCID 58424926, compound

Product 1

HCID 67410395HCID 67410395, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

The compound (40 mg, 0.120 mmol) prepared in step 7 was dissolved in ethanol (3 ml), added with 12 N hydrochloric acid (2 ml). The resulting mixture was refluxed for 12 hours at 90° C. Once the reaction was completed, the mixture was concentrated under reduced pressure and the residue was washed ethyl acetate to obtain the title compound (36 mg, yield: 84%, yellow solid).

Workup

  1. concentrationthe mixture was concentrated under reduced pressure
  2. washthe residue was washed ethyl acetate

Sources & evidence

ORD record
ord-d365572a105543f0a265bcbd813e291e
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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