Hydrochloric Acid → HCID 67381332, compound

HRID 2409425Notes

Reaction equation

HRID 2409425 reaction equation
[CH3:1][N:2]([CH3:23])[CH2:3][CH2:4][C:5]1[CH:22]=[CH:21][C:8]2[N:9](COC)[C:10](=[O:17])[C:11]3[CH2:12][CH2:13][CH2:14][NH:15][C:16]=3[C:7]=2[CH:6]=1.[ClH:24]>C(O)C>[ClH:24].[ClH:24].[CH3:23][N:2]([CH3:1])[CH2:3][CH2:4][C:5]1[CH:22]=[CH:21][C:8]2[NH:9][C:10](=[O:17])[C:11]3[CH2:12][CH2:13][CH2:14][NH:15][C:16]=3[C:7]=2[CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58424861HCID 58424861, compound

Product 1

HCID 67381332HCID 67381332, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

The compound (20 mg, 0.06 mmol) prepared in step 7 was dissolved in ethanol (4 ml) and added with conc. hydrochloric acid (0.5 ml). The resulting mixture was stirred for 8 hours at 80° C. and cooled to room temperature. The mixture was then concentrated under reduced pressure to obtain the title compound (18 mg, yield: 82%, yellow solid).

Workup

  1. temperaturecooled to room temperature
  2. concentrationThe mixture was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-6b04e977c3cf41a3b622d6479f339fcf
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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