Hydrochloric Acid → HCID 67381244, compound

HRID 2409434Notes

Reaction equation

HRID 2409434 reaction equation
[CH3:1][N:2]([CH3:24])[CH2:3][CH2:4][CH2:5][C:6]1[CH:23]=[CH:22][C:9]2[N:10](COC)[C:11](=[O:18])[C:12]3[CH2:13][CH2:14][CH2:15][NH:16][C:17]=3[C:8]=2[CH:7]=1.[ClH:25]>C(O)C>[ClH:25].[ClH:25].[CH3:24][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][C:6]1[CH:23]=[CH:22][C:9]2[NH:10][C:11](=[O:18])[C:12]3[CH2:13][CH2:14][CH2:15][NH:16][C:17]=3[C:8]=2[CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58424853HCID 58424853, compound

Product 1

HCID 67381244HCID 67381244, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound (112 mg, 0.34 mmol) prepared in step 9 was dissolved in ethanol (3 ml) and added with 12 N hydrochloric acid (2 ml). The resulting mixture was refluxed for 12 hours. Once the reaction was completed, the mixture was concentrated and recrystallized from methanol/ethyl acetate to obtain the title compound (110 mg, yield: 90%, yellow solid).

Workup

  1. temperatureThe resulting mixture was refluxed for 12 hours
  2. concentrationthe mixture was concentrated
  3. customrecrystallized from methanol/ethyl acetate

Sources & evidence

ORD record
ord-531fd2a8d3cd41ec9957521176e87cdb
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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