Hydrochloric Acid → HCID 67381404, compound

HRID 2409438Notes

Reaction equation

HRID 2409438 reaction equation
[CH3:1][N:2]([CH3:21])[C:3]1[CH:4]=[CH:5][C:6]2[C:15]3[NH:14][CH2:13][CH2:12][CH2:11][C:10]=3[C:9](=[O:16])[N:8](COC)[C:7]=2[CH:20]=1.[ClH:22]>C(O)C>[ClH:22].[CH3:1][N:2]([CH3:21])[C:3]1[CH:4]=[CH:5][C:6]2[C:15]3[NH:14][CH2:13][CH2:12][CH2:11][C:10]=3[C:9](=[O:16])[NH:8][C:7]=2[CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67381302HCID 67381302, compound

Product 1

HCID 67381404HCID 67381404, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

The compound (100 mg, 0.34 mmol) prepared in step 3 was dissolved in ethanol (5 ml) and added with conc. hydrochloric acid (1.0 ml). The mixture was stirred overnight at 80° C., cooled to room temperature, and concentrated under reduced pressure to obtain the title compound (89.6 mg, yield: 92%, yellow solid).

Workup

  1. temperaturecooled to room temperature
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-2dfb274999c048f090da80b96dfd2f3c
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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