Dimethylamine, hydrochloride → HCID 178493497, compound

HRID 2409788Notes

Reaction equation

HRID 2409788 reaction equation
Cl.[CH3:2][NH:3][CH3:4].[CH:5]([C:7]1[N:8]=[C:9]([NH:12][C:13]([C:15]2[C:16]3[N:17]=[CH:18][CH:19]=[N:20][C:21]=3[C:22]([C:25]3[C:30]([F:31])=[C:29]([O:32][CH3:33])[CH:28]=[C:27]([O:34][CH3:35])[C:26]=3[F:36])=[CH:23][CH:24]=2)=[O:14])[NH:10][CH:11]=1)=O>C(Cl)Cl.CO>[CH3:2][N:3]([CH2:5][C:7]1[N:8]=[C:9]([NH:12][C:13]([C:15]2[C:16]3[N:17]=[CH:18][CH:19]=[N:20][C:21]=3[C:22]([C:25]3[C:30]([F:31])=[C:29]([O:32][CH3:33])[CH:28]=[C:27]([O:34][CH3:35])[C:26]=3[F:36])=[CH:23][CH:24]=2)=[O:14])[NH:10][CH:11]=1)[CH3:4]

Participants

4

Reactant 2

HCID 10473Dimethylamine, hydrochlorideHCID 178493498HCID 178493498, compound

Product 1

HCID 178493497HCID 178493497, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 180 but using dimethylamine hydrochloride (1.5 equiv) instead of N,N,N′-trimethylethylenediamine and 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-formyl-1H-imidazol-2-yl)-amide (Example 7). Title compound: ES-MS: 469 [M+H]+; tR=3.14 min (System 1); TLC: Rf=0.22 (DCM/MeOH/NH3aq, 91.5:7.5:1).

Workup

  1. customThe title compound was prepared in analogy to the procedure

Sources & evidence

ORD record
ord-85f994ebee054378a9979b5f924b7b76
Source dataset
uspto-grants-2014_08
Patent number
US08815901B2

Reaction notes

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