反应详情

温度

68 °C

6.4 kg of methyl 2,4-bisbenzyloxy-5-bromobenzoate in 18 l of THF are added to a solution of 3 kg of sodium hydroxide in 30 l of water. After stirring overnight at 68° C., the mixture is cooled to 10° C., and 7.5 l of HCl (w: 37%) are added via a dropping funnel (pH 1). The mixture is stirred for a further 1 h and subsequently filtered. The residue is dried to constant weight in vacuo at 60° C.; 5.687 kg (91%) of 2,4-bisbenzyloxy-5-bromo-benzoic acid (m.p. 150-152° C.; MW 413.3).

1. temperaturethe mixture is cooled to 10° C.
2. stirringThe mixture is stirred for a further 1 h
3. filtrationsubsequently filtered
4. customThe residue is dried to constant weight in vacuo at 60° C.