Isobutyl chloroformate → HCID 66820542, compound

HRID 241031Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH:10]1([C:13](Cl)=O)[CH2:12][CH2:11]1.Cl[C:17]([O:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[O:18]>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[C:13]([CH:10]3[CH2:11][CH2:12]3)[N:8]([C:17]([O:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[O:18])[C:5]2=[N:6][CH:7]=1

Participants

Reactant 3

HCID 62365Isobutyl chloroformate

HCID 77637Cyclopropanecarbonyl chloride

HCID 6911565-Bromopyridine-2,3-diamine

Product 1

HCID 66820542HCID 66820542, compound

Procedure

Synthesized according to the method of reagent preparation 19 by using 5-bromo-2,3-diaminopyridine and acylation with cyclopropylcarbonyl chloride in step 1 and treatment with isobutyl chloroformate in step 3. MS (EI) for C14H16BrN3O2: 339 (MH+).

Workup

customSynthesized
customaccording to the method of reagent preparation 19

Sources & evidence

ORD record: ord-16941b968b25453abeb24483e3e6e157
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08648066B2

Reaction notes

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