Hydroxylamine → tert-butyl N-{4-[amino(hydroxyimino)methyl]benzyl}-N-methylglycinate

HRID 2410515Notes

Reaction equation

HRID 2410515 reaction equation
[NH2:1][OH:2].[C:3]([C:5]1[CH:21]=[CH:20][C:8]([CH2:9][N:10]([CH3:19])[CH2:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[CH:7][CH:6]=1)#[N:4]>CCO>[NH2:4][C:3](=[N:1][OH:2])[C:5]1[CH:6]=[CH:7][C:8]([CH2:9][N:10]([CH3:19])[CH2:11][C:12]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:13])=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 66678135tert-butyl N-(4-cyanobenzyl)-N-methylglycinate

Product 1

HCID 76685327tert-butyl N-{4-[amino(hydroxyimino)methyl]benzyl}-N-methylglycinate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 50% aqueous solution of hydroxylamine (13.25 mL, 225 mmol) was added at once into a solution of tert-butyl N-(4-cyanobenzyl)-N-methylglycinate (11.70 g, 45 mmol) in EtOH (75 mL).

Sources & evidence

ORD record
ord-b41010fcebc1451f9dfbeda54257b590
Source dataset
uspto-grants-2014_08
Patent number
US08815919B2

Reaction notes

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