3-Methyl-3-buten-1-ol → HCID 131731807, compound
Reaction equation
[CH3:1][C:2]([CH2:4][CH2:5][OH:6])=[CH2:3].[CH3:7][S:8](Cl)(=[O:10])=[O:9]>C(N(CC)CC)C>[CH:5]([O:6][S:8]([CH3:7])(=[O:10])=[O:9])=[CH:4][C:2](=[CH2:1])[CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
An example of the method for synthesizing Compound (1) includes a method described below in Production Examples 1 and 2. In such a method, first, isoprenol is reacted with methanesulfonyl chloride in the presence of a base such as triethylamine to obtain methanesulfonic acid isoprenyl ester. Next, if needed, the obtained product is isolated and purified by a conventional method, and the obtained methanesulfonic acid isoprenyl ester is reacted with a malonic acid dialkyl ester in the presence of a base such as sodium ethoxide. As needed, a neutralization step is carried out using an acid to obtain Compound (1).
Sources & evidence
- ORD record
- ord-9f9d801efe004a47be41b7cb4594db53
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08816123B2
Reaction notes
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